High-Molecular-Weight Kininogen

A plasma protein, molecular weight of 110 kD, that normally exists in plasma in a 1:1 complex with PREKALLIKREIN. HMWK is split by plasma kallikrein to produce BRADYKININ. The complex is a cofactor in the activation of coagulation factor XII. The product of this reaction, XIIa, in turn activates prekallikrein to KALLIKREINS. (From Stedman, 26th ed)

Also Known As:

Kininogen, High Molecular Weight; HMWK; Kininogen, High-Molecular-Weight; Fitzgerald Factor; High Molecular Weight Kininogen; High Molecular Weight Kininogens; High-Molecular-Weight Kininogens; Kininogens, High Molecular Weight; Kininogens, High-Molecular-Weight

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intercellular Signaling Peptides and Proteins: 29768
    - Kinins: 2029
      - Kininogens: 453
        High-Molecular-Weight Kininogen: 210
  - Blood Proteins: 12459
    - Blood Coagulation Factors: 5376
      - Kininogens: 453
        High-Molecular-Weight Kininogen: 210
  - Protein Precursors: 37
    - Kininogens: 453
      - High-Molecular-Weight Kininogen: 210
- Peptides: 82426
  - Intercellular Signaling Peptides and Proteins: 29768
    - Kinins: 2029
      - Kininogens: 453
        High-Molecular-Weight Kininogen: 210
Biological Factors: 2472
- Intercellular Signaling Peptides and Proteins: 29768
  - Kinins: 2029
    - Kininogens: 453
      - High-Molecular-Weight Kininogen: 210
- Blood Coagulation Factors: 5376
  - Kininogens: 453
    - High-Molecular-Weight Kininogen: 210
- Inflammation Mediators: 1113
  - Autacoids: 276
    - Kinins: 2029
      - Kininogens: 453
        High-Molecular-Weight Kininogen: 210

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Disease

Drug/Important Bio-Agent (IBA)